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KMID : 0363219950330020287
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Korean Journal of Dermatology
1995 Volume.33 No. 2 p.287 ~ p.293
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Efficacy of 1% Butenafine Hydrochloride Cream in the Treatement of Tinea pedis
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Abstract
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Background :
@EN Topical 1% butenafine hydrochloride cream, a new benzylamine derivative, has been reported to have antimycotic effect.
@ES Objective :
@EN An open trial was conducted to assess the efficacy and safety of 1% butenafine hydrochloride cream used once daily in the treatment of tinea pedias.
@ES Methods :
@EN Of 45 patients with clinically and mycologically proven tinea pedis from the department of dermatology at Kosin medical college hospital, 42 patients who could be monitored to the end of this study were evaluated. They applied 1% butenafine
hydrochloride cream once daily until clinical improvement became evident or for 4 weeks and the effects were evaluated clinically and mycologically.
@ES Results :
@EN 1. From the mycological studies at the initial visit, causative organisms were isolated from 36 patients out of the 42 subjects and Trichophyton rubrum was most common organism.
2. The negative conversion rate of the mycological study(negative microscopy and negative culture) was 90.5%(38/42) after 4 weeks of treatment.
3. The effective treatment rate at 4 weeks was 90.5%(38/42).
4. A adverse effects ofusing 1% butenafine hydrochloride cream was noted in 1 patient who had a moderate degree of pruritus, out of the 42 subjects. The pruritus disappeared soon after the cessation of application of the cream.
@ES Conclusion :
@EN 1% butenafine hydrochloride cream is effective and safe in the treatment of tinea pedis. (Kor J Dermatol 1995;33(2) : 287~293)
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